(PD) is a multifaceted inflammatory disease
connected to bacterial infection that results in the destruction of tooth supporting structures and eventually tooth loss
. Given their involvement in infection and inflammation, both metallothionein
(MT) and zinc (Zn) might play vital roles in the development and progression of PD. More specifically, both MT and Zn are heavily involved in regulating immune functions, controlling bacterial infection, balancing inflammatory responses, and reducing oxidative stress
, all of which are associated with the pathogenesis of PD.